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A new model to evaluate the viability of supercooled rabbit heart for transplantation.

Author(s) : EBINE K., TAMURA S., LEE M., et al.

Type of article: Article

Summary

31P-NMR spectroscopy was introduced into preserved rabbit hearts, and the effects of simple hypothermia (4 deg C) and supercooling (-3 deg C) with cold cardioplegia were studied. The levels of creatine phosphate and adenosine triphosphate (ATP) of donor hearts rapidly declined during surgical procedure to remove the heart from the donor rabbits, but the inorganic phosphate level tended to rise. The levels of creatine phosphate and ATP in the supercooled group were significantly better maintained as compared to those in the simple hypothermic group. Much earlier recovery of myocardial energy metabolism during reperfusion was also observed in the supercooled group. These results suggest that NMR will be a useful nondestructive tool to evaluate graft hearts before transplantation, and supercooling will keep the grafts in better condition.

Details

  • Original title: A new model to evaluate the viability of supercooled rabbit heart for transplantation.
  • Record ID : 1993-1138
  • Languages: English
  • Source: Probl. Cryobiol. - n. 1
  • Publication date: 1992
  • Document available for consultation in the library of the IIR headquarters only.

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