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Actions of selected hepatotoxicants on freshly isolated and cryopreserved rat hepatocytes.

Author(s) : PANG J. M., ZALESKI J., KAUFFMAN F. C.

Type of article: Article

Summary

The study compares the actions of the hepatotoxic agents allyl alcohol, acetaminophen, and carbon tetrachloride on energy metabolism in freshly isolated and cryopreserved rat hepatocytes. The results suggest that increased sensitivity to hepatotoxic agents and elevated oxygen consumption in cryopreserved hepatocytes recovered after storage in liquid nitrogen are related to higher demand for energy in these cells rather than to permanent injury caused by cryopreservation and irreversible uncoupling of oxidative phosphorylation.

Details

  • Original title: Actions of selected hepatotoxicants on freshly isolated and cryopreserved rat hepatocytes.
  • Record ID : 1997-0551
  • Languages: English
  • Source: Cryobiology - vol. 33 - n. 2
  • Publication date: 1996/04

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