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AN ANALYTICAL METHOD TO EVALUATE COOLING RATES DURING CRYOPRESERVATION PROTOCOLS FOR ORGANS.

Author(s) : RUBINSKY B., CRAVALHO E. G.

Type of article: Article

Summary

A SIMPLE, GRAPHICAL PROCEDURE HAS BEEN ESTABLISHED TO ESTIMATE THE COOLING RATES AT A SPECIFIED LOCATION AND TEMPERATURE IN A BIOLOGICAL MEDIUM FROZEN BY IMPOSING A CONSTANT COOLING RATE AT THE OUTER SURFACE. THE GRAPHICAL PROCEDURE ALSO FACILITATES THE DETERMINATION OF THE OUTER SURFACE TEMPERATURE AT THE INSTANT A GIVEN TEMPERATURE HAS BEEN ATTAINED IN A SPECIFIC LOCATION. THE RESULTS OBTAINED THROUGH A NUMERICAL STUDY USING FINITE ELEMENTS CAN BE APPLIED TO BIOLOGICAL MEDIA WITH VARIOUS CHEMICAL COMPOSITIONS INCLUDING DIFFERENT CONCENTRATIONS OF CRYOPROTECTIVE AGENTS.

Details

  • Original title: AN ANALYTICAL METHOD TO EVALUATE COOLING RATES DURING CRYOPRESERVATION PROTOCOLS FOR ORGANS.
  • Record ID : 1985-0823
  • Languages: English
  • Source: Cryobiology - vol. 21 - n. 3
  • Publication date: 1984

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