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THE EFFECT OF COOLING AND WARMING RATE ON CORTICAL CELL FUNCTION OF GLYCEROLIZED RABBIT KIDNEYS.

Author(s) : PEGG D. E.

Type of article: Article

Summary

PREVIOUS EXPERIMENTS SUGGESTED THAT RABBIT KIDNEYS PERMEATED WITH 2 M GLYCEROL ARE LEAST DAMAGED IF THEY ARE COOLED VERY SLOWLY (1 K/HR). USING SIMILAR TECHNIQUES OF GLYCEROLIZATION, ACTIVE CELL FUNCTION IN CORTICAL TISSUE SLICES PREPARED FROM SUCH KIDNEYS HAS NOW BEEN STUDIED. KIDNEYS COOLED AT 3.1 K/MIN AND WARMED AT 4.2 K/MIN GAVE POOR RESULTS. KIDNEYS COOLED AT 1 K/HR EXHIBITED DEGREES OF SLICE FUNCTION THAT WERE DEPENDENT ON WARMING RATE: WARMING AT 1 K/MIN WAS BETTER THAN WARMING AT 1 K/HR OR 20 K/MIN. THESE RATES ARE MUCH LOWER THAN HAVE HITHERTO BEEN USED BY OTHERS FOR ANY SYSTEM.

Details

  • Original title: THE EFFECT OF COOLING AND WARMING RATE ON CORTICAL CELL FUNCTION OF GLYCEROLIZED RABBIT KIDNEYS.
  • Record ID : 1985-1297
  • Languages: English
  • Source: Cryobiology - vol. 21 - n. 5
  • Publication date: 1984

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