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AN ANALYTICAL STUDY ON THE PROCESS OF FREEZING AND THE MECHANISM OF DAMAGE DURING CRYOSURGERY.

Author(s) : RUBINSKY B., ETO T. K., ONIK G.

Summary

A NEW ENERGY EQUATION WAS DEVELOPED TO DESCRIBE THE PROCESS OF FREEZING IN BIOLOGICAL TISSUE. EXPERIMENTAL OBSERVATIONS SHOW THAT DURING FREEZING ICE FORMS IN THE BLOOD VESSELS WHICH EXPAND IN VOLUME BY AS MUCH AS A FACTOR OF 4. THIS EXPANSION IS PROBABLY RESPONSIBLE FOR THE DAMAGE TO THE TISSUE DURING CRYOSURGERY. THE NEW EQUATION WAS USED TO DERIVE AN EXPRESSION FOR THE RELATIVE DISTANCE BETWEEN THE LOCATION AT WHICH THE BLOOD VESSELS EXPAND TO THEIR MAXIMAL RADIUS AND THE OUTER EDGE OF THE FROZEN REGION DURING CRYOSURGERY. AN EVALUATION OF THE EXPRESSION FOR TYPICAL PARAMETERS DURING FREEZING OF LIVER SHOWS THAT THE MAXIMAL EXPANSION OF THE BLOOD VESSELS OCCURS AT A TEMPERATURE AS HIGH AS 270.5 (-2.5 DEG C) AND AT A DISTANCE OF 0.1 MM FROM THE OUTER EDGE OF THE FROZEN REGION.

Details

  • Original title: AN ANALYTICAL STUDY ON THE PROCESS OF FREEZING AND THE MECHANISM OF DAMAGE DURING CRYOSURGERY.
  • Record ID : 1990-2637
  • Languages: English
  • Publication date: 1989/10/11
  • Source: Source: Proc. 7th int. Congr. Cryosurg., Beijing
    118-126; 1 fig.; 1 tabl.; 12 ref.
  • Document available for consultation in the library of the IIR headquarters only.

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