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Beneficial effect of intracellular trehalose on viability of freeze-dried red blood cells.

[In Chinese. / En chinois.]

Author(s) : HE H., LIU B. L., HUA Z. H., et al.

Type of article: Article

Summary

Currently, freeze-drying is one of the best methods for the preservation of red blood cells. The effects of intracellular trehalose on the viability of freeze-dried red blood cells were investigated. The fresh red blood cells were incubated in trehalose solutions of various concentrations at 37°C for 7 hours. The results show that the intracellular trehalose concentration increased with the increasing concentration of extracellular trehalose solution. The maximum concentration of intracellular trehalose was 35 mmol/L in the study. Red blood cells loaded with trehalose were lyophilized with the concentrations of trehalose of 15, 22.5, 30 and 37.5% respectively. The results show that the viability of freeze-dried red blood cells increased with the increase of intracellular trehalose concentration.

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Pages: 41-44

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Details

  • Original title: [In Chinese. / En chinois.]
  • Record ID : 2006-3218
  • Languages: Chinese
  • Source: Journal of Refrigeration - vol. 27 - n. 109
  • Publication date: 2006/06

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