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BIOCHEMICAL MODIFICATION AND CRYOPRESERVATION OF RED BLOOD CELLS COLLECTED IN CPD-A.

Author(s) : LEIDERMAN I. Z., ROTH E. F. Jr, ZAROULIS C. G.

Summary

THE ADDITION OF ADENINE TO THE ANTICOAGULANT CITRATE PHOSPHATE DEXTROSE (CPD) HAS INCREASED THE STORAGE OF BLOOD PRESERVED AT 4 DEG C FROM 21 TO 35 DAYS. THE AUTHORS HAVE DEMONSTRATED THAT CPD-A BLOOD CAN BE BIOCHEMICALLY MODIFIED OR REJUVENATED ON DAY 35 OF STORAGE AND SUCCESSFULLY CRYOPRESERVED. THE REJUVENATED RED-CELLS WERE CRYOPRESERVED BY THE SERIAL ADDITION TO 1.25 TIMES THEIR VOLUME OF 6.2 M GLYCEROL. DATA DEMONSTRATE THAT BLOOD COLLECTED IN THE ANTICOAGULANT, CPD-A CAN BE BIOCHEMICALLY MODIFIED (REJUVENATED) AND SUCCESSFULLY CRYOPRESERVED. THUS, BLOOD COLLECTED IN CPD-A CAN BE SALVAGED FOR TRANSFUSION ON THE DAY OF OUTDATING BY REJUVENATION AND FREEZING.

Details

  • Original title: BIOCHEMICAL MODIFICATION AND CRYOPRESERVATION OF RED BLOOD CELLS COLLECTED IN CPD-A.
  • Record ID : 1982-2107
  • Languages: English
  • Publication date: 1981/12/05
  • Source: Source: Am. Soc. Hematol., Annu. Meet., San Antonio, TX
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