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Cold chain validation for home-based intravenous chemotherapy: a last mile example.

Number: pap. ID: 731

Author(s) : BENIZRI F., BONAN B., MITTAINE-MARZAC B., et al.

Summary

Home-based intravenous chemotherapy requires cold chain validation to ensure thermo-sensitive products are maintain at the correct temperature from production unit of pharmacy department to patient’s home. The aim of this study is, firstly, to validate thermal performances of packaging and, secondly, to monitor the cold chain in real conditions with traceability to the last mile. Thermal performances of packagings were tested, by a COFRAC accredited laboratory (Cemafroid) according to the NF S99700 AFNOR standard. Conditions of validation were defined in the worst-case conditions. On 22 configurations of packaging provided by 3 suppliers and tested in climatic chamber, 41 % (9/22) are not compliant. In real conditions, 2.5% (7/281) of cases of non compliant have been observed between October 2009 and December 2010. None of cold chain failure was explained by thermal performance of packaging. This experiment, with example of home-based chemotherapy, represents a novel approach in the hospital world of validation of the cold chain with a perfect example of last mile.

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Pages: 8 p.

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Details

  • Original title: Cold chain validation for home-based intravenous chemotherapy: a last mile example.
  • Record ID : 30002150
  • Languages: English
  • Source: Proceedings of the 23rd IIR International Congress of Refrigeration: Prague, Czech Republic, August 21-26, 2011. Overarching theme: Refrigeration for Sustainable Development.
  • Publication date: 2011/08/21

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