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Securing of cooling steps before packaging: example of home-based intravenous chemotherapy logistics process.

Number: pap. ID: 730

Author(s) : BENIZRI F., DERENS E., DELAHAYE A., et al.

Summary

Quality approach of home-based intravenous chemotherapy requires cold chain validation to secure transport from production unit of pharmacy department to patient’s home. In practice, the cooling time before packaging is a significant step. The objective is to assess a “rapid” cooling and define a model of heat transfer. Chemotherapy preparations are simulated with several syringes and bags containing sodium chloride. After fifteen compared tests, the difference of cooling time averages from room temperature to 5°C is statistically significant for every device between “rapid” and “standard” cooling (student’s test, p<0.001). The prototype allows the cooling process to be accelerated with a lower uncertainly of temperature measurement. In the current practice, the use of abacuses defined by the heat transfer model allows the sensitive step of home-based intravenous chemotherapy logistics process to be secured.

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Pages: 7 p.

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Details

  • Original title: Securing of cooling steps before packaging: example of home-based intravenous chemotherapy logistics process.
  • Record ID : 30002148
  • Languages: English
  • Source: Proceedings of the 23rd IIR International Congress of Refrigeration: Prague, Czech Republic, August 21-26, 2011. Overarching theme: Refrigeration for Sustainable Development.
  • Publication date: 2011/08/21

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