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CRYOPRESERVATION AND TRANSPLANTATION OF HEPATOCYTES: AN APPROACH FOR CULTURE AND CLINICAL APPLICATION.

Author(s) : MAGANTO P.

Type of article: Article

Summary

THE AUTHORS STUDIED DIFFERENT MEDIA AND PROCEDURES OF FREEZING, AND HAVE CHOSEN THAT COMBINATION WHICH AFFORDED THE BEST RESULTS FOR LONG-TERM STUDIES OF FUNCTION. A SERIES OF INTRASPLENIC TRANSPLANTS WERE PERFORMED WITH FRESHLY ISOLATED HEPATOCYTES AS WELL AS CRYOPRESERVED ONES, AND SEVERAL HEPATOSPECIFIC PARAMETERS WERE QUANTIFIED FOR 9 MONTHS. THE HISTOLOGICAL STUDY OF THE CELLS REVEALS THAT THEY ACQUIRED AN ARCHITECTURE CHARACTERISTIC OF THE LIVER. THE RESULTS INDICATE THE POSSIBILITY OF RECOVERING HEPATOCYTES WHICH MAINTAIN THEIR SPECIFIC FUNCTIONS AFTER BEING SUBJECTED TO A FREEZING-THAWING PROCESS.

Details

  • Original title: CRYOPRESERVATION AND TRANSPLANTATION OF HEPATOCYTES: AN APPROACH FOR CULTURE AND CLINICAL APPLICATION.
  • Record ID : 1989-2078
  • Languages: English
  • Source: Cryobiology - vol. 25 - n. 4
  • Publication date: 1988

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