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CRYOPRESERVATION OF MURINE BONE MARROW CELL WITH A VIEW TO ALLOGENEIC BONE MARROW TRANSPLANTATION.

Author(s) : DING Z.

Summary

MURINE BONE MARROW CELLS WERE CRYOPRESERVED IN LIQUID NITROGEN WITH A PROGRAMMABLE FREEZING SYSTEM. THE RESULTS SHOWED THAT CFU-GRANULOCYTE-MONOCYTE IN A GRAFT WAS SLIGHTLY AFFECTED BY FREEZING, WITH A RECOVERY OF 75.7%, BUT CFU-S WHICH PLAYS A MAJOR ROLE IN HEMATOPOIETIC RECONSTITUTION WAS NOT OBVIOUSLY INJURED (RECOVERY OF 126.7%). IN THE TRANSPLANTATION STUDY, THE FROZEN-THAWED MARROW CELLS INCREASED THEIR SURVIVAL RATE BY 43.6%, WHICH WAS SLIGHTLY HIGHER THAN THAT ATTAINED BY FRESH CELLS, SUGGESTING THAT CRYOPRESERVED MARROW CELLS STILL HAVE INTACT HEMATOPOIETIC RECONSTRUCTIVE ABILITY.

Details

  • Original title: CRYOPRESERVATION OF MURINE BONE MARROW CELL WITH A VIEW TO ALLOGENEIC BONE MARROW TRANSPLANTATION.
  • Record ID : 1990-2602
  • Languages: English
  • Publication date: 1989/10/11
  • Source: Source: Proc. 7th int. Congr. Cryosurg., Beijing
    145-149; 3 fig.; 3 tabl.; 8 ref.
  • Document available for consultation in the library of the IIR headquarters only.

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