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Cryopreserved osteochondral allograft.

[In Japanese. / En japonais.]

Author(s) : KIM W., NAMIE K., ARAI Y., HIRASAWA Y.

Type of article: Article

Summary

In reconstruction of the destroyed joint by an osteochondral allograft, there are two indispensable conditions. One is the prevention of graft rejection, and the other is the survival of chondrocytes. It is relatively easy to satisfy only the latter. Using fresh allograft may be the answer. However, fresh osteochondral allograft is difficult to implant due to antigenicity of bone. In contrast, treatments for the depression of immune response to the bone cause the death of chondrocytes. That is the dilemna of osteochondral allografts. Can cryopreservation satisfy the two conditions at the same time? Solution of this problem is necessary but not sufficient enough for the success of cryopreserved osteochondral allograft. Chondrocytes live surrounded by cartilage matrix. Further, change of matrix affected by the cryopreservation is not a trivial matter.

Details

  • Original title: [In Japanese. / En japonais.]
  • Record ID : 1998-1308
  • Languages: Japanese
  • Source: Low Temperature Medicine - vol. 22 - n. 4
  • Publication date: 1996/12
  • Document available for consultation in the library of the IIR headquarters only.

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