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Cryoprotective effect of glycine in cold stored canine renal tubules.

Author(s) : SAUNDER A., AMETANI M. S., BELZER F. O., SOUTHARD J. H.

Type of article: Article

Summary

The authors determined the effects of glycine on viability of isolated canine renal tubules. Renal tubules were cold stored at 4 deg C under hypoxic conditions for up to 96 hours in the University of Wisconsin solution and rewarmed to 37 deg C for up to 2 hours under oxygenated conditions to simulate reperfusion of an organ after cold static storage. Short-term storage (24-48 hours) did not cause membrane injury (leakage of lactate dehydrogenase) on rewarming. However, after 72 and 96 hours cold storage reperfusion injury was evident and lactate dehydrogenase leakage increased from about 25 to 59 more or less 3% and 71 more or less 2% at 72 and 96 hours cold storage, respectively.

Details

  • Original title: Cryoprotective effect of glycine in cold stored canine renal tubules.
  • Record ID : 1994-1872
  • Languages: English
  • Source: Cryobiology - vol. 30 - n. 3
  • Publication date: 1993/06

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