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Cryopreservation-induced enhancement of interleukin-2 production in human peripheral blood mononuclear cells.

Author(s) : VENKATARAMAN M.

Type of article: Article

Summary

To better understand the effects of cryopreservation on various immunocompetent cell functions, the authors have examined the interleukin-2 (IL-2) producing activities of frozen mononuclear cells (MNCs) from healthy subjects. The mechanisms responsible for the observed effects were also analyzed. Both the unfractionated and monocyte-depleted, frozen MNCs produced significantly larger quantities of IL-2 than fresh cells. The results provided further evidence that the lack of active, suppressor T cells, monocytes, and increased IL-1 and -2 production may be responsible for the previously reported enhanced immunoglobin-producing abilities of cryopreserved cells from healthy subjects and from patients with lung cancer.

Details

  • Original title: Cryopreservation-induced enhancement of interleukin-2 production in human peripheral blood mononuclear cells.
  • Record ID : 1993-0525
  • Languages: English
  • Source: Cryobiology - vol. 29 - n. 2
  • Publication date: 1992/04

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