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Effects on cryopreservation upon vein function in vivo.

Author(s) : BROCKBANK K. G. M.

Type of article: Article

Summary

The review covers experimental and clinical experiences with transplantation of allogenic veins processed by slow rate cooling with 2.5% (W/V) chondroitin sulfate and 1 M DMSO. These results are contrasted with the results obtained using DMSO alone. The short-term patency of experimental autologous (100%) and allogenic (70-100%) cryopreserved veins are explained. Explanted allografts demonstrate short-term loss of endothelial cells and smooth muscle function, both of which subsequently return. Clinically, there have been positive short-term correlations between good initial runoff from the graft site and 1-year patency (68-74%) and limb salvage (94%) rates. When longer follow-up is still necessary, chondroitin sulfate-preserved veins are used for coronary artery bypass or peripheral bypass patients in the absence of suitable autologous vessels.

Details

  • Original title: Effects on cryopreservation upon vein function in vivo.
  • Record ID : 1995-1220
  • Languages: English
  • Source: Cryobiology - vol. 31 - n. 1
  • Publication date: 1994/02

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