Share

IIR document

FREEZE-DRYING OF OXYHEMOGLOBIN IN PRESENCE OF ALPHA-D-GLUCOSE AND MESO-INOSITOL.

CRYODESSICCATION D'OXYHEMOGLOBINE EN PRESENCE D'ALPHA-D-GLUCOSE ET DE MESO-INOSITOL.

Author(s) : CHAILLOT B.

Summary

FREEZE-DRYING OF HEMOGLOBIN LEADS TO THE FORMATION OF AN IMPORTANT AMOUNT OF METHEMOGLOBIN. IT IS POSSIBLE TO DECREASE THIS TRANSFORMATION BY THE PRESENCE OF PROTECTIVE COMPOUNDS. THE MECHANISM OF ACTION OF THESE PROTECTORS IS UNKNOWN. CIRCULAR DICHROISM SPECTRA BETWEEN 250 AND 700 NANOMETRES ARE PRESENTED FOR SAMPLES OF HEMOGLOBIN FREEZE-DRIED WITH OR WITHOUT PROTECTION AND FOR CONTROL SOLUTIONS OF OXYHEMOGLOBIN AND METHEMOGLOBIN. THE INTERPRETATION OF THE DICHROIC SPECTRA ALLOWS TO OBTAIN TERTIARY AND QUATERNARY STRUCTURE CHANGES THAT HEMOGLOBIN UNDERGOES BY FREEZE-DRYING. THE ABSENCE OF A PROTECTOR INFLUENCES WEAKLY THE CONFORMATION IN THE VICINITY OF THE HEME.

Available documents

Format PDF

Pages: 127-130

This document is to be digitised and will be available within 10 working days

  • Public price

    20 €

  • Member price*

    Free

* Best rate depending on membership category (see the detailed benefits of individual and corporate memberships).

Details

  • Original title: CRYODESSICCATION D'OXYHEMOGLOBINE EN PRESENCE D'ALPHA-D-GLUCOSE ET DE MESO-INOSITOL.
  • Record ID : 1985-1334
  • Languages: French
  • Source: [Refrigeration serving humanity]. Proceedings of the XVIth international Congress of Refrigeration.
  • Publication date: 1983/08/07
  • Document available for consultation in the library of the IIR headquarters only.

Links


See other articles from the proceedings (541)
See the conference proceedings

Indexing