Share

STABILITY AND FUNCTIONAL PROPERTIES OF FREEZE-DRIED HEMOGLOBIN IN PRESENCE OF FOUR PROTECTANTS AFTER 15 MONTH STORAGE: DOSE-EFFICIENCY RELATIONSHIP.

STABILITE ET PROPRIETES FONCTIONNELLES D'HEMOGLOBINE LYOPHILISEE EN PRESENCE DE QUATRE PROTECTEURS APRES 15 MOIS DE CONSERVATION : RELATIONS DOSE - EFFICACITE.

Author(s) : LABRUDE P., VIGNERON C., STREIFF F.

Summary

HEMOGLOBIN LYOPHILISATES PROTECTED DURING DRYING BY SUCROSE, ARGININ ASPARTATE, LYSIN ASPARTATE, SODIC-ZINCIC EDTA OR FICOLL 70 WERE STORED IN AIR AT 4 DEG C OVER 15 MONTHS. A CONCENTRATION OF 0.12 M SUCROSE AND AMINO-ACID SALT PREVENTS OXIDATION. THE RELATIONSHIPS BETWEEN THE CONCENTRATIONS OF THESE COMPOUNDS AND METHEMOGLOBIN RATIO PRIOR TO AND AFTER STORAGE DEFINE THE THEORETICALLY SUFFICIENT DOSES OF PROTECTANT FOR PREVENTING THE FORMATION OF METHEMOGLOBIN OVER 15 MONTHS. SUCROSE IS SLIGHTLY MORE EFFICIENT THAN THE AMINO-ACID SALT. EDTA AND FICOLL 70 DO NOT ENSURE LONG PRESERVATION.

Details

  • Original title: STABILITE ET PROPRIETES FONCTIONNELLES D'HEMOGLOBINE LYOPHILISEE EN PRESENCE DE QUATRE PROTECTEURS APRES 15 MOIS DE CONSERVATION : RELATIONS DOSE - EFFICACITE.
  • Record ID : 1983-2422
  • Languages: French
  • Publication date: 1982/07/08
  • Source: Source: Congr. natl. Transfus. sang., Saint-Etienne
    n. 12.

Indexing