Identification of a cold receptor reveals a general role for TRP channels in thermosensation.

Author(s) : MCKEMY D. D., NEUHAUSSER W. M., JULIUS D.

Type of article: Article

Summary

The cellular and molecular mechanisms that enable us to sense cold are not well understood. Insights into this process have come from the use of pharmacological agents, such as menthol, that elicit a cooling sensation. The authors have characterized and cloned a menthol receptor from trigeminal sensory neurons that is also activated by thermal stimuli in the cold range.

Details

  • Original title: Identification of a cold receptor reveals a general role for TRP channels in thermosensation.
  • Record ID : 2002-3171
  • Languages: English
  • Source: Nature - vol. 416 - n. 6876
  • Publication date: 2002/03/07
  • Document available for consultation in the library of the IIR headquarters only.

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