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Immunological response after cryosurgery for malignant tumours.

[In Japanese. / En japonais.]

Author(s) : NAKAZAKI H., WATANABE M., HASEBE Y., et al.

Type of article: Article

Summary

Cryosurgical immunoreaction for malignant tumours has both advantages and disadvantages. Immunological response after cryosurgery, PHA induced lymphoblastogenesis, CD4, CD8, CD11b and CD25 positivity in peripheral blood, were referred to. The merits and demerits of incomplete frozen tumour was also discussed. Non-specific cell immunity after cryosurgery may be induced, as PHA blast formation, CD4 and CD11b positivity in peripheral blood are higher than before cryosurgery. But specific cell immunity in the early period after cryosurgery may not be so induced, as CD8 and CTL activity after cryosurgery are not higher than before cryosurgery. It cannot be denied that specific cell immunity subsequently occurs. However, cryosurgery for large tumours and under lapalotomy may cause severe damage for patients, and negative immunity may be induced in the early period after cryosurgery. The authors note the need to take care of negative immunity in the early period after cryosurgery. The remaining tumour after complete freezing may be bigger than before, so the authors have to perform complete cryosurgical destruction of the tumour.

Details

  • Original title: [In Japanese. / En japonais.]
  • Record ID : 2004-2524
  • Languages: Japanese
  • Source: Low Temperature Medicine - vol. 28 - n. 1
  • Publication date: 2002/03
  • Document available for consultation in the library of the IIR headquarters only.

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