Study on high zone tolerance induced by freeze-thawing tumour immunization and its preventive effect by combination with immunopotentiators.

[In Japanese. / En japonais.]

Author(s) : URANO M., TANAKA C., SUGIYAMA Y., et al.

Type of article: Article


In addition to the therapeutic effect caused by thermal damage of the tumour cells in the frozen aera, cryosurgery has some immunological effect by absorption of freezing-thawing tumour tissue (FTT). On the other hand, it also shows a promoting effect of tumour growth at the step of massive absorption of FTT, that is high zone tolerance. In the present study, the authors examined anti-tumour immunoreactivity induced by FTT using a metastasic hepatic tumour by intra-portal inoculation of colon 26 to BALB/c mouse and the combined effect with the biological response modifier (BRM) such as PSK and OK-432. The following results were obtained: 1) in terms of comparison with 100 mg FTT inoculation survival day was significantly prolonged and number of metastatic nodules of the liver was reduced in 50 mg FTT; 2) in the case of combination use with FTT and BRM, the number of metastatic nodules was significantly reduced in the PSK group, but slightly increased in the OK-432 group; 3) NK and CTL activity of splenocyte showed a higher value in the 50 mg group compared with the 100 mg group and it increased when combined with PSK.


  • Original title: [In Japanese. / En japonais.]
  • Record ID : 2004-2519
  • Languages: Japanese
  • Source: Low Temperature Medicine - vol. 28 - n. 1
  • Publication date: 2002/03
  • Document available for consultation in the library of the IIR headquarters only.


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