Magnetocaloric effect applied for a cancer tumour defeat: an improved hyperthermia method.

Efecto magnetocalórico aplicado para destruir un tumor cancerígeno: un método mejorado de hipertermia.

Author(s) : ZATSEPINA E., TISHIN A., EGOLF P. W., et al.

Type of article: Article

Summary

In this study, Gd and the alloy Fe(49)Rh(51) are considered to be possible magnetocaloric materials for a new hyperthermia method. From general principles of thermodynamics a new mathematical model allowing the calculation of heat transport in a tumour was developed and numerical simulations were performed. The heating-up time as a dependence of the size and mass of a spherical tumour is determined. Estimates of the necessary frequency in dependence of the particle concentration and temperature are presented. In the case of Gd nanoparticles, approximate and accurate calculations are made by assuming that the covering material of the particles consist of poly(N-isopropylacrylamide) hydrogel. Dynamic heat transfer processes are graphically visualized.

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Pages: 17-25 (8 p.)

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