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Phospholipid peroxidation in isolated perfused rat hearts subjected to hypothermia followed by rewarming: inverse relation to loss of function.

Author(s) : YTREHUS K., ASPANG E. M.

Type of article: Article

Summary

Stable normotherm perfusion (37 deg C) for 20 minutes was followed by cooling to 14 deg C, 4 h perfusion at 14 deg and rewarming to 37 deg C, followed by 30 min of normotherm perfusion. After rewarming there was a significant reduction in mechanical performance and coronary flow. Tissue content of high-energy phosphates decreased and tissue water content increased. Membrane destabilization due to increase in phospholipid peroxidation cannot explain these results.

Details

  • Original title: Phospholipid peroxidation in isolated perfused rat hearts subjected to hypothermia followed by rewarming: inverse relation to loss of function.
  • Record ID : 1995-0559
  • Languages: English
  • Source: Cryobiology - vol. 31 - n. 3
  • Publication date: 1994/06

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