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PHYSICAL PROBLEMS WITH THE VITRIFICATION OF LARGE BIOLOGICAL SYSTEMS.

Author(s) : FAHY G. M., SAUR J., WILLIAMS R. J.

Type of article: Article

Summary

THE PAPER FOCUSES ON CONCERNS WHICH ARE PARTICULARLY RELEVANT TO SYSTEMS RANGING FROM 10 MILLILITERS TO 1.5 LITERS. NEW QUALITATIVE DATA ARE PROVIDED ON THE EFFECT OF SAMPLE SIZE ON THE PROBABILITY OF NUCLEATION AND THE ULTIMATE SIZE OF THE RESULTING ICE CRYSTALS AS WELL AS ON THE PROBABILITY OF FRACTURE. COOLING RATE HAS A PROFOUND INFLUENCE ON THE TEMPERATURE-DEPENDENT PROCESSES OF NUCLEATION AND CRYSTAL GROWTH IN 47-50% (W/W) SOLUTIONS FOO FRACTURING DEPENDS STRONGLY ON COOLING RATE AND THE PRESENCE OF A CARRIER SOLUTION REDUCES THE CONCENTRATION OF CRYOPROTECTANT NEEDED FOR VITRIFICATION.

Details

  • Original title: PHYSICAL PROBLEMS WITH THE VITRIFICATION OF LARGE BIOLOGICAL SYSTEMS.
  • Record ID : 1991-2778
  • Languages: English
  • Source: Cryobiology - vol. 27 - n. 5
  • Publication date: 1990

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