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RELATIONSHIP BETWEEN THE DEGREE OF LYSOSOME AND MITOCHONDRIA STRUCTURAL CHANGES ON FREEZE-THAWING AND THE RELEASE OF PROTEIN SYNTHESIS INHIBITOR.

Author(s) : ZAGNOJKO V. I.

Type of article: Article

Summary

THE CHANGES AT VARIOUS TEMPERATURES, AT WHICH THE INHIBITING EFFECT OF ORGANELLE CRYOEXTRACTS ON THE PROTEIN-SYNTHETIZING ACTIVITY OF RAT LIVER CELL-FREE SYSTEM IS APPARENTLY MANIFESTED, HAS BEEN STUDIED. IT HAS BEEN FOUND THAT MITOCHONDRIA HAVE GREATER SUSCEPTIBILITY TO THE EFFECT OF LOW TEMPERATURES THAN LYSOSOMES AND THAT SUPERCOOLING OF MITOCHONDRIAL SUSPENSION DOWN TO THE TEMPERATURE OFFREE-WATER CRYSTALLIZATION DOES NOT RESULT IN THE RELEASE OF PROTEIN SYNTHESIS INHIBITOR. THE RELEASE OF INHIBITOR BEGINS FROM THE MOMENT OF CRYSTALLIZATION AND REACHES ITS MAXIMUM AT EUTECTIC TEMPERATURES DUE TO THE DAMAGING EFFECT ON MEMBRANE STRUCTURES OF PHYSICO-CHEMICAL FACTORS.

Details

  • Original title: RELATIONSHIP BETWEEN THE DEGREE OF LYSOSOME AND MITOCHONDRIA STRUCTURAL CHANGES ON FREEZE-THAWING AND THE RELEASE OF PROTEIN SYNTHESIS INHIBITOR.
  • Record ID : 1986-0420
  • Languages: English
  • Source: Cryo-Letters - vol. 6 - n. 3
  • Publication date: 1985
  • Document available for consultation in the library of the IIR headquarters only.

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