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The effect of Amphotericin B on the viability of cryopreserved human skin.

Author(s) : VILLALBA R., ALONSO P., VILLALBA J. M., RIOJA L. F., GOMEZ VILLAGRAN J. L.

Type of article: Article

Summary

To evaluate whether amphotericin B has a detrimental effect on the viability of cryopreserved skin, human skin samples were incubated for 7 and 24 hours in three different media: 0.9% phosphate-buffered saline and Medium 199 with and without 10 micrograms per millilitre amphotericin B. A significant decrease in cryopreserved human skin viability was observed after 7 and 24 hour incubation with amphotericin B. These results indicate that in the processing of skin preservation, the beneficial effect of using amphotericin B as an antifungal agent may be reduced by its negative effect on tissue viability.

Details

  • Original title: The effect of Amphotericin B on the viability of cryopreserved human skin.
  • Record ID : 1996-1893
  • Languages: English
  • Source: Cryobiology - vol. 32 - n. 4
  • Publication date: 1995/08

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