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THE < UNFROZEN FRACTION > HYPOTHESIS OF FREEZING INJURY TO HUMAN ERYTHROCYTES: A CRITICAL EXAMINATION OF THE EVIDENCE.

Author(s) : PEGG D. E., DIAPER M. P.

Type of article: Article

Summary

THE PAPER EXAMINES THE EXPERIMENTAL EVIDENCE PRESENTED BY MAZUR AND HIS COLLEAGUES TO SUPPORT THEIR HYPOTHESIS THAT THE SURVIVAL OF SLOWLY FROZEN HUMAN RED BLOOD CELLS IS PRIMARILY DEPENDENT ON THE FRACTION OF WATER THAT REMAINS UNFROZEN, RATHER THAN ON THE HIGH CONCENTRATIONS OF SODIUM CHLORIDE PRODUCED BY THE FORMATION OF ICE. THE AUTHORS BELIEVE THAT THE KNOWN EFFECTSOF VARIATIONS IN COOLING AND WARMING RATE, AND IN HEMATOCRIT, ARE ABLE TO ACCOUNT FOR THE FEATURES OBSERVED BY MAZUR AND HIS COLLEAGUES IN THEIR 3 PUBLISHED STUDIES.

Details

  • Original title: THE < UNFROZEN FRACTION > HYPOTHESIS OF FREEZING INJURY TO HUMAN ERYTHROCYTES: A CRITICAL EXAMINATION OF THE EVIDENCE.
  • Record ID : 1990-0409
  • Languages: English
  • Source: Cryobiology - vol. 26 - n. 1
  • Publication date: 1989

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