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The preservation of viability of BCG vaccine freeze-dried in a new extracellular protector, evaluated by ATP-dependent bioluminescence assay.

Author(s) : POPESCU C., BALAZS D., TASCA G., PITUR I., OFITERU A, NASCUTIU A. M.

Type of article: Article

Summary

A new protective medium CP-94 (a combination of sodium glutamate and sorbitol), with cryoprotective properties and supposed to have the capacity to counteract the osmotic shock during the rehydration stage, was used in an attempt to preserve the long term viability of the freeze-dried BCG vaccine. The CP-94 protective medium allowed preserving the cell viability level of the BCG vaccine at 80-90% of the initial value. This medium enhances the quality of the Romanian BCG vaccine as it facilitates preservation of the number of viable units per dose as well as the extension of the long-term stability to two years.

Details

  • Original title: The preservation of viability of BCG vaccine freeze-dried in a new extracellular protector, evaluated by ATP-dependent bioluminescence assay.
  • Record ID : 2000-0438
  • Languages: English
  • Source: Cryo-Letters - vol. 20 - n. 2
  • Publication date: 1999/03
  • Document available for consultation in the library of the IIR headquarters only.

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