Share

Antifreeze proteins induce intracellular nucleation.

Author(s) : LARESE A., ACKER J., MULDREW K., YANG H., MCGANN L.

Type of article: Article

Summary

Antifreeze proteins (AFPs) have a natural ability to prevent freezing in several species, thus encouraging attempts to use antifreeze proteins in artificial cryoprotection. The study shows that the addition of type I antifreeze proteins from winter flounder increases the incidence of intra-cellular ice formation in animal cells at high subzero temperatures, resulting in reduced recovery of cryopreserved cells. These observations are consistent with the concept that AFP binding to a growing ice crystal allows ice to interact physically with the plasma membrane, thereby facilitating the increased incidence of intracellular nucleation.

Details

  • Original title: Antifreeze proteins induce intracellular nucleation.
  • Record ID : 1997-1142
  • Languages: English
  • Source: Cryo-Letters - vol. 17 - n. 3
  • Publication date: 1996/05
  • Document available for consultation in the library of the IIR headquarters only.

Links


See other articles in this issue (8)
See the source

Indexing