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CELL MEMBRANE SURFACE AREA CHANGES RELATED TO METABOLIC AND OSMOTIC BEHAVIOUR IN ISOLATED RAT HEPATOCYTES AFTER FREEZING AND HYPERTONIC EXPOSURE.

Author(s) : FULLER B. J., GROUT B. W., JAMES E.

Type of article: Article

Summary

UPON SINGLE EXPOSURE TO A HYPERTONIC SOLUTION, OR AFTER A SINGLE FREEZING EPISODE WHEN CELLS WERE COOLED BELOW 263 K (-10 DEG C) IN THE ABSENCE OF CRYOPROTECTANT, METABOLIC VIABILITY WAS SEVERELY REDUCED. HOWEVER, THESE SAME CELLS WERE ABLE TO RESPOND OSMOTICALLY TO A SECOND, IDENTICAL HYPERTONIC STRESS IN A MANNER QUANTITATIVELY SIMILAR TO THAT DURING THE FIRST. THE IMPLICATIONS OF THESE FINDINGS FOR STUDIES ON HEPATOCYTE CRYOPRESERVATION ARE DISCUSSED.

Details

  • Original title: CELL MEMBRANE SURFACE AREA CHANGES RELATED TO METABOLIC AND OSMOTIC BEHAVIOUR IN ISOLATED RAT HEPATOCYTES AFTER FREEZING AND HYPERTONIC EXPOSURE.
  • Record ID : 1985-1293
  • Languages: English
  • Source: Cryo-Letters - vol. 5 - n. 4
  • Publication date: 1984
  • Document available for consultation in the library of the IIR headquarters only.

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