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CRYOMICROSCOPY OF LIPOSOME SYSTEMS AS SIMPLE MODELS TO STUDY CELLULAR FREEZING RESPONSE.

Author(s) : MACGRATH J. J.

Type of article: Article

Summary

LIPOSOMES REPRESENT AN ATTRACTIVE MODEL SYSTEM TO STUDY THE FREEZE/THAW INDUCED ALTERATIONS IN BIOLOGICAL MEMBRANES PRIMARILY BECAUSE LIPOSOMES MAY BE CUSTOM-MANUFACTURED FOR A PARTICULAR INVESTIGATION. IT IS SIGNIFICANT TO NOTE THAT IN VIRTUALLY EVERY CATEGORY THUS FAR EXAMINED THE RELEVANT CRYOBIOLOGICAL BEHAVIOUR OF BIOLOGICAL CELLS CAN BE MIMICKED QUALITATIVELY (AND IN SOME CASES QUANTITATIVELY) BY A PURE LIPID MEMBRANE SYSTEM. THE LIPOSOME MODEL SYSTEM OFFERS SOME INTERESTING POSSIBILITIES OF EXAMINING THE RELATIVE IMPORTANCE OF LIPIDS AND PROTEINS IN MODEL SYSTEMS. CRYOMICROSCOPIC OBSERVATION OF LIPOSOME SYSTEMS REPRESENTS A PROMISING APPROACH TO AN IMPROVED UNDERSTANDING OF MEMBRANE-RELATED PHENOMENA WHICH OCCUR DURING FREEZING AND THAWING.

Details

  • Original title: CRYOMICROSCOPY OF LIPOSOME SYSTEMS AS SIMPLE MODELS TO STUDY CELLULAR FREEZING RESPONSE.
  • Record ID : 1985-0337
  • Languages: English
  • Source: Cryobiology - vol. 21 - n. 1
  • Publication date: 1984

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