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THE RESPONSE OF MULTILAMELLAR LIPOSOMES TO FREEZING AND THAWING.

Author(s) : MORRIS G. J., MCGRATH J. J.

Type of article: Article

Summary

MODIFICATION OF THE LIPOSOME PHOSPHOLIPID AND CHOLESTEROL CONTENT ALLOWS A CORRELATION TO BE MADE BETWEEN THE COMPOSITION OF A MEMBRANE SYSTEM AND ITS RESPONSE TO THE STRESSES OF FREEZING AND THAWING. THE RESPONSE OF LIPOSOMES FOLLOWING COOLING AT A RANGE OF RATES TO 77K (-196 DEG C) AND THE EFFECTS OF CRYOPROTECTIVE ADDITIVES ARE SIMILAR TO THOSE OBSERVED WITH MANY CELL TYPES. THESE RESULTS INDICATE THAT LIPOSOMES ARE A VALID MODEL FOR INVESTIGATING THE BIOCHEMISTRY OF MEMBRANE DAMAGE INDUCED BY THE STRESSES OF FREEZING AND THAWING.

Details

  • Original title: THE RESPONSE OF MULTILAMELLAR LIPOSOMES TO FREEZING AND THAWING.
  • Record ID : 1982-1037
  • Languages: English
  • Source: Cryobiology - vol. 18 - n. 4
  • Publication date: 1981/08

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