Ethylene glycol permeation and toxicity in the rabbit common carotid artery.

Author(s) : WUSTEMAN M., BUSZA A., BOYLAN S., HAYES A., PEGG D.

Type of article: Article

Summary

Ethylene glycol is shown to be a cryoprotectant that permeates sufficiently rapidly into small elastic arteries to achieve cryoprotective tissue concentrations after relatively short periods of exposure. It is nontoxic at temperatures close to 0 deg C, both for the smooth muscle and the vascular endothelium, even at concentrations approaching those capable of causing vitrification. Therefore, ethylene glycol warrants further investigation as a possible cryoprotectant for the preservation of arteries for clinical use.

Details

  • Original title: Ethylene glycol permeation and toxicity in the rabbit common carotid artery.
  • Record ID : 1996-1892
  • Languages: English
  • Source: Cryobiology - vol. 32 - n. 5
  • Publication date: 1995/10

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