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The effect of cooling rate and temperature on the toxicity of ethylene glycol (EG) in the rabbit internal carotid artery.

Author(s) : WUSTEMAN M., BOYLAN S., PEGG D. E.

Type of article: Article

Summary

Forty percent EG has substantial toxic effects on both the smooth muscle and the vascular endothelium of the rabbit common carotid artery. The effects on smooth muscle cannot be overcome by changing the cooling rate, or by reducing the temperature at which high concentrations of the cryoprotectant are introduced. Although endothelial cell permeability to propidium iodide can be attenuated by reducing the temperature of exposure, cooling also leads to detachment of the cell layer from the basement membrane. It therefore is unlikely that EG is a suitable cryoprotectant for use in vascular tissue.

Details

  • Original title: The effect of cooling rate and temperature on the toxicity of ethylene glycol (EG) in the rabbit internal carotid artery.
  • Record ID : 1997-1150
  • Languages: English
  • Source: Cryobiology - vol. 33 - n. 4
  • Publication date: 1996/08

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