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INTRODUCTION AND REMOVAL OF CRYOPROTECTIVE AGENTS WITH RABBIT KIDNEYS: ASSESSMENT BY TRANSPLANTATION.

Author(s) : JACOBSEN I. A.

Type of article: Article

Summary

RABBIT KIDNEYS WERE PERFUSED WITH UP TO 4 M GLYCEROL OR PROPYLENE GLYCOL (PG) IN 3 VEHICLE SOLUTIONS: ONE NORMOKALEMIC AND MADE HYPERTONIC WITH MANNITOL (HP5), ONE HYPERKALEMIC WITHOUT MANNITOL (HP6), AND ONE HYPERKALEMIC AND WITH MANNITOL (HP7). SUBSEQUENT FUNCTION WAS ASSESSED BY AUTOTRANSPLANTATION. UP TO 3 M GLYCEROL IN HP5 WAS WELL TOLERATED BUT NOT IN HP6 OR HP7. CONVERSELY, UP TO 3 M PG IN HP7 WAS COMPATIBLE WITH EXCELLENT POST-TRANSPLANT FUNCTION, BUT THE SAME CONCENTRATION IN HP5 WASSEVERELY DAMAGING. PG (4 M) IN EITHER SOLUTION WAS SEVERELY INJURIOUS. THE OBSERVATION OF DAMAGE AT HIGH SUBZERO TEMPERATURES, BEFORE FREEZING HAS OCCURRED, REQUIRES FURTHER DETAILED STUDY.

Details

  • Original title: INTRODUCTION AND REMOVAL OF CRYOPROTECTIVE AGENTS WITH RABBIT KIDNEYS: ASSESSMENT BY TRANSPLANTATION.
  • Record ID : 1989-2079
  • Languages: English
  • Source: Cryobiology - vol. 25 - n. 4
  • Publication date: 1988

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