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FACTORS INFLUENCING RENAL CRYOPRESERVATION. I. EFFECTS OF THREE VEHICLE SOLUTIONS AND THE PERMEATION KINETICS OF THREE CRYOPROTECTANTS ASSESSED WITH RABBIT CORTICAL SLICES.

Author(s) : CLARK P., FAHY G. M., KAROW A. M. Jr

Type of article: Article

Summary

A RENAL CORTICAL SLICE MODEL WAS USED TO ASSESS THE EFFECTS ON VIABILITY OF THREE VEHICLE SOLUTIONS. TRACER TECHNIQUES WERE USED TO STUDY THE OSMOTIC EFFECTS AND PERMEATION KINETICS AT 298 K (25 DEG C) OF THREE CRYOPROTECTANTS (DMSO, ETHYLENE GLYCOL, AND GLYCEROL). IT WAS FOUND THAT DMSO WAS MOST PERMEABLE AND ETHYLENE GLYCOL LEAST, AND THAT ETHYLENE GLYCOL HAD UNUSUAL EFFECTS WHICH SUGGEST THAT IT MAY NOT ACT AS A SIMPLE SOLUTE.

Details

  • Original title: FACTORS INFLUENCING RENAL CRYOPRESERVATION. I. EFFECTS OF THREE VEHICLE SOLUTIONS AND THE PERMEATION KINETICS OF THREE CRYOPROTECTANTS ASSESSED WITH RABBIT CORTICAL SLICES.
  • Record ID : 1985-0824
  • Languages: English
  • Source: Cryobiology - vol. 21 - n. 3
  • Publication date: 1984

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