Share

Mechanisms of tissue injury in cryosurgery.

Author(s) : GAGE A. A., BAUST J.

Type of article: Article

Summary

All parts of the freeze-thaw cycle can cause tissue injury. The cooling rate should be as fast as possible, but it is not as critical as other factors. The coldest tissue temperature is the prime factor in cell death and this should be -50 deg C in neoplastic tissue. The optimal duration of freezing is not known, but prolonged freezing increases tissue destruction. The thawing rate is a prime destructive factor and it should be as slow as possible. Repetition of the freeze-thaw cycle is well known to be an important factor in effective therapy. A prime need in cryosurgical research is related to the periphery of the cryosurgical lesion where some cells die and others live. Adjunctive therapy should influence the fate of cells in this region and increase the efficacy of cryosurgical techniques.

Details

  • Original title: Mechanisms of tissue injury in cryosurgery.
  • Record ID : 1999-3914
  • Languages: English
  • Source: Cryobiology - vol. 37 - n. 3
  • Publication date: 1998/11

Links


See other articles in this issue (6)
See the source

Indexing