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Physical observations on rapid freezing of tumour cells to -40 deg C using differential scanning calorimetry.

Author(s) : SHAKHS S. el-, SHIMI S., BENSON E. E., NEWMAN L., CUSCHIERI A.

Type of article: Article

Summary

In this in vitro study, the authors have been able to define and explain an important parameter for effective clinical cryoablation. The results confirm that the sub-zero temperature reached, and rate of freezing used, constitute the crucial freezing variables for effective cryoablation. The only reliable method to ensure 100% tumour cell kill is the combination of rapid freezing to a sub-zero temperature of -40 deg C, or lower. The authors have also shown that the application of cryogenic treatments to cells which have already been cryoablated may also contribute to further cryodamage through further multiple ice nucleation events.

Details

  • Original title: Physical observations on rapid freezing of tumour cells to -40 deg C using differential scanning calorimetry.
  • Record ID : 1999-1940
  • Languages: English
  • Source: Cryo-Letters - vol. 19 - n. 3
  • Publication date: 1998/05
  • Document available for consultation in the library of the IIR headquarters only.

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