Share

Pressurisation of pharmaceutical cleanrooms.

Author(s) : BALIGA B. G.

Type of article: Article

Summary

Cleanroom spaces are maintained with pressure differentials between rooms as an important tool to achieve contamination control. By maintaining the room at a higher pressure, the products can be protected from contaminants from the adjoining spaces. On the other hand, potent products like penicillin and nuclear medicines can be kept in containment by maintaining the room at a lower pressure. Maintaining the required pressure gradient and ensuring that there are no airflow reversals pose peculiar challenges. Movement of personnel and materials between rooms involving opening and closing of doors, changing gaps between doors and frames due to wearing of gaskets and changing supply air, return air and exhaust air quantities are some of the variables which disturb the pressure differentials all the time. This article discusses the means to achieve and control the room pressure differentials for pharmaceutical cleanrooms and also indicates the energy consumed to maintain pressure gradient.

Available documents

Format PDF

Pages: 62-70 (6 p.)

Available

  • Public price

    20 €

  • Member price*

    15 €

* Best rate depending on membership category (see the detailed benefits of individual and corporate memberships).

Details

  • Original title: Pressurisation of pharmaceutical cleanrooms.
  • Record ID : 30011551
  • Languages: English
  • Source: Air Conditioning and Refrigeration Journal - vol. 17 - n. 2
  • Publication date: 2014/03

Links


See other articles in this issue (4)
See the source

Indexing