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Small, acid-soluble proteins bound to DNA protect Bacillus subtilis spores from being killed by freeze-drying.

Author(s) : FAIRHEAD H., SETLOW B., WAITES W. M., SETLOW P.

Type of article: Article

Summary

Wild-type spores of Bacillus subilis were resistant to eight cycles of freeze-drying, whereas about 90% of spores lacking the two major DNA-binding proteins (small, acid-soluble proteins alpha and beta) were killed by three to four cycles of freeze-drying, with significant mutagenesis and DNA damage accompanying the killing. This role for alpha/beta-type small, acid-soluble proteins in spore resistance to freeze-drying may be important in spore survival in the environment.

Details

  • Original title: Small, acid-soluble proteins bound to DNA protect Bacillus subtilis spores from being killed by freeze-drying.
  • Record ID : 1995-2572
  • Languages: English
  • Source: Appl. environ. Microbiol. - vol. 60 - n. 7
  • Publication date: 1994/07
  • Document available for consultation in the library of the IIR headquarters only.

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