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STUDIES ON THE CRYOPRESERVATION OF BONE MARROW.

Author(s) : LIU Z.

Type of article: Article

Summary

THE SUCCESSFULL TRANSPLANTING OF CRYOPRESERVED HEMATOPOIETIC STEM CELLS DEPENDS UPON THE FREEZING TECHNIQUE, THE CONTROL OF THE FREEZING RATE, THE CONDITION AND DURATION OF STORAGE AND THE NUMBER OF CELLS ENGRAFTED. AS CRYOPRESERVATIVE AGENTS THE AUTHOR USED A MIXTURE OF ALCOHOL AND DRY ICE FOR ONE EXPERIMENT AND LIQUID NITROGEN FOR ANOTHER. A SPECIAL DEVICE WAS DEVELOPED TO CONTROL THE FREEZING RATE. TESTS WERE CARRIED OUT AT 2 TEMPERATURE RANGES: 277 TO 243 K (4 TO -30 DEG C) AND 243 TO 193 K (-80 DEG C). FURTHER EXPERIMENTS ARE BEING UNDERTAKEN TO ASCERTAIN THE EFFECT OF THE FREEZING RATE ON CELL VIABILITY, THE USE OF CRYOPROTECTIVE ADDITIVES AND NEW METHODS OF PRESERVATION IN ORDER TO IMPROVE THE CLINICAL RESULTS OF TRANSPLANTS.

Details

  • Original title: STUDIES ON THE CRYOPRESERVATION OF BONE MARROW.
  • Record ID : 1988-2531
  • Languages: English
  • Source: Low Temperature Medicine - vol. 13 - n. 2
  • Publication date: 1987
  • Document available for consultation in the library of the IIR headquarters only.

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