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The glass transition temperature of mixtures of trehalose and hydroxyethyl starch.

Author(s) : CHEN T., BHOWMICK S., SPUTTEK A., et al.

Type of article: Article

Summary

Although mixtures of HES and sugars are used to preserve cells during freezing or drying, little is known about the glass transition of HES, or how mixtures of HES and sugars vitrify. These difficulties may be due to the polydispersity between HES samples or differences in preparation techniques, and problems in measuring the glass transition temperature using differential scanning calorimetry (DSC). In the report, the authors examine the glass transition of temperature of mixtures of HES and trehalose sugar with less than 1% moisture content using DSC measurements. By extrapolating these measurements to pure HES using the Gordon-Taylor and Fox equations, they estimated the glass transition temperature of the HES sample at 44 °C. This approach to estimating the glass transition temperature of HES may be useful in other cases where glass transitions are not easily identified.

Details

  • Original title: The glass transition temperature of mixtures of trehalose and hydroxyethyl starch.
  • Record ID : 2003-2043
  • Languages: English
  • Source: Cryobiology - vol. 44 - n. 3
  • Publication date: 2002/06

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