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THE MOLECULAR-CELLULAR CONCEPT OF CELL CRYOINJURY: THE ROLE OF TRANSMEMBRANE DEFECTS.

[In Russian. / En russe.]

Author(s) : BELOUS A. M., BONDARENKO V. A., GULEVSKIJ A. K.

Type of article: Article

Summary

BASING ON THE ANALYSIS OF EXPERIMENTAL RESULTS A MOLECULAR-CELLULAR CONCEPT OF CELL CRYOINJURY HAS BEEN PROPOSED WHICH SUGGESTS THAT STRUCTURAL CHANGES IN PLASMA MEMBRANE SEPARATING THE CELL INTERIOR FROM THE EXTERIOR ARE THE INITIAL STEP OF CRYOINJURY. FOUR PHASES IN THE DEVELOPMENT OF TRANSMEMBRANE DEFECTS (TMD) DURING STRUCTURAL CHANGES ARE OUTLINED: INITIATION, STABILIZATION, INCREASING THE SIZE OF TMD AND TMD REPARATION. THE POSSIBILITY OF TMD INITIATION APPEARED TO BE INDEPENDENT OF THE INITIAL TEMPERATURE AND OSMOTIC CONDITIONS OF THE CELL ENVIRONMENT.

Details

  • Original title: [In Russian. / En russe.]
  • Record ID : 1988-0386
  • Languages: Russian
  • Source: Kriobiologija - n. 2
  • Publication date: 1987
  • Document available for consultation in the library of the IIR headquarters only.

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