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Theoretical prediction of vitrification and devitrification tendencies for cryoprotective solutions.

Author(s) : REN H. S., WEI Y., HUA T. C., ZHANG J.

Type of article: Article

Summary

Based on Boutron's semi-empirical crystallization theory, exact analytical expressions for variation in the quantity of ice crystallized have been obtained by the integral method without using finite expansions. These expressions can be used to predict the glass-forming tendency and the stability of the amorphous state for cryoprotective agents, respectively. It is shown that an aqueous solution of L-2,3-butanediol has the highest glass-forming tendency and the most stable wholly amorphous state, followed by 1,2-propanediol and DMSO, ethylene glycol, and glycerol. It is also found that the high polymers have obvious non-Arrhenius properties. Therefore, the stability of the cryoprotective agents can be enhanced by adding polyvinyl pyrrolidone or polyethyleneglycol.

Details

  • Original title: Theoretical prediction of vitrification and devitrification tendencies for cryoprotective solutions.
  • Record ID : 1995-1207
  • Languages: English
  • Source: Cryobiology - vol. 31 - n. 1
  • Publication date: 1994/02

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