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COLD STORAGE PRESERVATION OF ISLET AND PANCREAS GRAFTS AS ASSESSED BY IN VIVO FUNCTION AFTER TRANSPLANTATION TO DIABETIC HOSTS.

Author(s) : SUTHERLAND D. E. R.

Type of article: Article

Summary

THE MAJOR GOAL OF HYPOTHERMIC: 277-281 K (4-8 DEG C) PRESERVATION OF INTACT PANCREASES OR ISOLATED ISLETS WILL BE TO PROVIDE SUFFICIENT TIME FOR HLA TYPING, CROSS MATCHING, SELECTION, AND PREPARATION OF RECIPIENTS -LOGISTICAL EFFORTS REQUIRING 12-72 HR FOR CLINICAL KIDNEY TRANSPLANTATION, USUALLY LESS THAN 48 HOURS. SOME INVESTIGATORS HAVE STUDIED IN VITRO FUNCTION OF ISLETS AFTER COLD STORAGE, BUT THE CRITICAL TEST OF VIABILITY (PERMANENT RESTORATION OF NORMOGLYCEMIA AFTER TRANSPLANTATION TO DIABETIC RECIPIENTS) HAS BEEN TESTED IN ONLY A FEW EXPERIMENTS.

Details

  • Original title: COLD STORAGE PRESERVATION OF ISLET AND PANCREAS GRAFTS AS ASSESSED BY IN VIVO FUNCTION AFTER TRANSPLANTATION TO DIABETIC HOSTS.
  • Record ID : 1984-1239
  • Languages: English
  • Source: Cryobiology - vol. 20 - n. 2
  • Publication date: 1983

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