ShareCRYOPRESERVATION OF HUMAN PLATELETS WITH PROPANE-1,2-DIOL.
Author(s) : ARNAUD F. G., PEGG D. E.
Type of article: Article
Summary
IN ATTEMPTS TO CRYOPRESERVE HUMAN PLATELETS, PROPYLENE GLYCOL (PG) CONCENTRATIONS OF 0.5, 1.0, 2.0, AND 2.5 M AND COOLING RATES BETWEEN 0.4 AND 100 K/MIN WERE STUDIED. IRRESPECTIVE OF THE INITIAL CONCENTRATION OF PG, THE EXTENT OF DAMAGE WAS CLOSELY CORRELATED WITH THE CONCENTRATION OF PG PRODUCED AT THE MINIMUM TEMPERATURE USED. THE TOXICITY OF PG INCREASES SO STEEPLY WITH THE INCREASING CONCENTRATION PRODUCED BY THE SEPARATION OF ICE DURING FREEZING THAT THIS EFFECT IS SUFFICIENT TO COUNTERACT THE CRYOPROTECTIVE ACTION OF THIS SOLUTE FOR PLATELETS.
Details
- Original title: CRYOPRESERVATION OF HUMAN PLATELETS WITH PROPANE-1,2-DIOL.
- Record ID : 1991-0883
- Languages: English
- Source: Cryobiology - vol. 27 - n. 2
- Publication date: 1990
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