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Current status of the use of frozen red cells: a review of problems with penetrating and non-penetrating cryoprotectants.

Author(s) : CAEKENBERGHE D. L. van

Type of article: Article

Summary

Nonpenetrating cryoprotectant-frozen blood and nonpenetrating cryoprotectant-lyophilized blood are known to suffer partial hemolysis after thawing and intravascular hemolysis after administration. As for the first unit of blood, this hemolysis is masked by binding of free hemoglobin to haptoglobin. But in the multiply transfused patient, several problems due to intravascular hemolysis should be dealt with: disseminated intravascular coagulation, acute renal failure, cardiac arrest.

Details

  • Original title: Current status of the use of frozen red cells: a review of problems with penetrating and non-penetrating cryoprotectants.
  • Record ID : 1997-3048
  • Languages: English
  • Source: Cryo-Letters - vol. 17 - n. 5
  • Publication date: 1996/09/10
  • Document available for consultation in the library of the IIR headquarters only.

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