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EFFECT OF COOLING RATE ON HUMAN AND MURINE HEMOPOIETIC PRECURSOR CELL RECOVERY.

Author(s) : NISKANEN E., PIRSCH G.

Type of article: Article

Summary

IN THE PRESENCE OF 10% DIMETHYL SULFOXIDE, A COOLING RATE OF 7 K/MIN FROM 269 TO 243 K (-4 TO -30 DEG C) WAS OPTIMAL FOR RECOVERY OF HUMAN AND MURINE PRECURSOR CELLS. COOLING OF HUMAN MARROW AT A RATE BETWEEN 3 AND 7 K/MIN RESULTED IN THE BEST RECOVERY, ALTHOUGH NO GOOD CORRELATION BETWEEN THE COOLING RATE AND MURINE RECOVERY WAS DEMONSTRATED. THESE DATA SUGGEST THAT RECOVERY OF THE PRIMITIVE HEMOPOIETIC PRECURSOR CELLS CAN BE IMPROVED BY CHANGING THE STANDARD CRYOPRESERVATION PROGRAMS.

Details

  • Original title: EFFECT OF COOLING RATE ON HUMAN AND MURINE HEMOPOIETIC PRECURSOR CELL RECOVERY.
  • Record ID : 1984-1246
  • Languages: English
  • Source: Cryobiology - vol. 20 - n. 4
  • Publication date: 1983

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