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Equations for obtaining melting points for the ternary system ethylene glycol/sodium chloride/water and their application to cryopreservation.

Author(s) : WOODS E. J., ZIEGER M. A. J., GAO D. Y., et al.

Type of article: Article

Summary

The paper describes the H2O-NaCl-ethylene glycol ternary system by using a differential scanning calorimeter to measure melting points of four different ratios (R) of ethylene glycol to NaCl and then devising equations to fit the experimental measurements. An equation is derived which characterizes the liquidus surface above the eutectic for any R value in the system. This study focuses on ethylene glycol in part because of recent evidence indicating it may be less toxic to pancreatic islets than DMSO, which is currently used routinely for islet cryopreservation. The resulting data and previously determined information on the osmotic characteristics of canine pancreatic islets are combined in a mathematical model to describe the volumetric response to equilibrium-rate freezing in varying initial concentrations of ethylene glycol.

Details

  • Original title: Equations for obtaining melting points for the ternary system ethylene glycol/sodium chloride/water and their application to cryopreservation.
  • Record ID : 2000-2240
  • Languages: English
  • Source: Cryobiology - vol. 38 - n. 4
  • Publication date: 1999/06

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