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Improved freezing injury of in vitro brain tumour cells by use of nanoparticle adjuvants.

Author(s) : DENG Z. S., ZHANG H., LIU J., et al.

Summary

Along with the development of modern imaging techniques, cryosurgery is emerging as an important minimally invasive surgical method for treatment of brain tumours. Although imaging allows excellent control over the freezing extent, enhancement of cryosurgical injury of tumour cells at freezing temperature is also preferred to improve cryosurgical outcome. The goal of this study is to find effective cryosurgical adjuvants to enhance freezing injury of brain tumour cells. Considering the important role of ice crystal formation in freezing induced cell injury, nanoparticles were introduced in this study to produce more ice crystals and thus to enhance freezing injury of tumour cells. Cellular suspensions of brain tumour with and without nanoparticles were respectively frozen using a cryosurgical apparatus with two freeze-thaw cycles. The viability of brain tumour cells was then assessed by typan blue dye exclusion. The results indicate that nanoparticles significantly increase cellular destruction. It suggests that nanoparticles may be effective adjuvants to cryosurgical treatment of brain tumours.

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Pages: ICR07-C1-1172

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Details

  • Original title: Improved freezing injury of in vitro brain tumour cells by use of nanoparticle adjuvants.
  • Record ID : 2008-0949
  • Languages: English
  • Source: ICR 2007. Refrigeration Creates the Future. Proceedings of the 22nd IIR International Congress of Refrigeration.
  • Publication date: 2007/08/21

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