Pioneers in cryobiology : Julius von Sachs (1832-1897)

Author(s) : DILLER K. R.

Type of article: Article


Julius Sachs is considered to be one of the founding fathers of modern plant physiology, and he was also a pioneering researcher in cryobiology. He applied his skill in the design of novel instrumentation to perform the first analysis of freezing and thawing processes in tissues under direct microscopic observation. His experiments led him to identify a number of fundamental phenomena that govern the freeze-thaw behaviour of cells. These include the formation of extracellular ice and the consequent dehydration of entrapped cells, damage to the cell membrane during freezing and thawing with loss in selective permeability function, and the evolution of absorbed gases as bubbles. His interpretation of these results was strongly biased toward describing the injury process in terms of events associated with the thawing protocol.


  • Original title: Pioneers in cryobiology : Julius von Sachs (1832-1897)
  • Record ID : 1997-2468
  • Languages: English
  • Source: Cryo-Letters - vol. 17 - n. 4
  • Publication date: 1996/07
  • Document available for consultation in the library of the IIR headquarters only.


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